Disease characteristics and Outcome of Malignant Ovarian Germ Cell Tumors in a tertiary care centre of India

Abstract

Aims and Objectives - To study the demographic profile, disease characteristics and outcome of Malignant Ovarian Germ Cell Tumors

Material & Methods –  This retrospective study was conducted on 50 cases of Malignant Ovarian Germ Cell Tumors (MOGCT) diagnosed over a period of five years in a tertiary care teaching hospital. Institutional ethical clearance was obtained and informed consent was taken from all participants. The case records were reached for demographic, clinical, investigational and treatment details. Patients were contacted telephonically to know their current health status. Data was tabulated and analysed to find the overall survival, recurrence and disease free survival.

Results -  The median age at diagnosis was 21 years. The most common presenting symptom was abdominal pain or pressure reported in 54% cases. Majority (72%) of cases presented in stage I and 40% underwent fertility preservation surgery with unilateral oophorectomy. About 20 % cases underwent primary cytoreductive surgery and 8% received  neoadjuvant chemotherapy followed by interval cytoreductive surgery. The most common histopathological types were dysgerminoma (40%) and mixed germ cell tumor (35%). Out of 50 cases, survival outcomes were available for 37cases. The median follow up duration was 30.4 month. The 3 year overall survival was 100% and disease free survival was 92%. Recurrence was seen in 12% cases. Two cases had a favourable fertility outcome after treatment.

Conclusions – MOGCT is a disease of young women of reproductive age group with a good survival & fertility outcome with standard treatment protocols.